If an applicant abandons a petition or application filed with USCIS, meaning that they fail to appear for appointments, interviews, or respond to requests from USCIS, the application or petition will be denied. The denial becomes a part of the applicant's "A File" (aka Alien Registration File), and is a permanent record. Depending on the circumstances of the abandonment, there may be stronger scrutiny of a later-filed petition, especially if the abandonment is not the only one, or if the applicant has filed more than one spousal petition or application in the past.
It's important to remember that, while there may not be specific regulations or guidance explaining the impacts of an abandonment or withdrawal, I-485 green card applications are discretionary, which means that they can be denied by USCIS even if it appears that the applicant meets the standard admissibility requirements. If a USCIS officer believes that an applicant's marriage is not in good faith or is for purposes of immigration, or that the applicant has shown a pattern of attempting to gain immigration benefits through marriage, this can lead to much more difficult interviews in the future, up to and including potential denials.